• In the CNS histamine is known to regulate sleep

  2022-08-01

  

  In the CNS, Vidofludimus receptor is known to regulate sleep and wakefulness, learning and memory, feeding, and energy. Here, we address its actions in relation to CNS disorders, and emphasize potential clinical applications of histamine receptor ligands (Table 1). In addition, as the effect of hist

• Compared to the other histamine receptor subtypes the H

  2022-08-01

  

  Compared to the other AK-7 receptor receptor subtypes, the H3 receptor exhibits rather complex pharmacology, being subject to extensive splicing, leading to two major (H3-445 and H3-365) and possibly more functional human receptor isoforms; for a comprehensive review please see Leurs et al. (2005)

• However HDACi can also increase the

  2022-07-30

  

  However, HDACi can also increase the acetylation of other transcription factors that regulate p65 transcriptional activity. The HDACi-induced activation of p65 can be negated by acetylated STAT1, which can specifically bind to p65 and inhibit its transcriptional activity 81, 82, 83. Interestingly, a

• However HDACi can also increase the

  2022-07-30

  

  However, HDACi can also increase the acetylation of other transcription factors that regulate p65 transcriptional activity. The HDACi-induced activation of p65 can be negated by acetylated STAT1, which can specifically bind to p65 and inhibit its transcriptional activity 81, 82, 83. Interestingly, a

• Similar to Rac Cdc and RhoA expression

  2022-07-30

  

  Similar to Rac1, Cdc42, and RhoA, expression of Rnd3 is also increased under hypoxic conditions, involving Hif1α mediated transcriptional activity. Here, downregulation of Rnd3 abolishes hypoxia-induced cell migration via a mechanism involving the chemokine receptor C-X-C motif chemokine receptor 4

• An interesting question is why RhoF has

  2022-07-30

  

  An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino GGsTop mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid sequence of RhoF, rather than t

• br Introduction Inflammatory bowel diseases IBDs including C

  2022-07-29

  

  Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis (Baumgart and Sandborn, 2012; Beaugerie et al., 2006) are typically characterized by chronic, progressive, and relapsing inflammation of the intestine. Although the exact pathogenesis of IBD is unknow

• Migratory properties of Treg are

  2022-07-29

  

  Migratory properties of Treg are extremely important for the potential in vivo application. Therefore, the observed expression of CXCR3 on almost all obtained insulin-specific Treg is crucial for directing 5-Methoxy-CTP into the inflamed tissue (in this case pancreatic islets). CXCR3 responds to CX

• br Material and methods br Results Consistent

  2022-07-29

  

  Material and methods Results Consistent with our previous study, SR-SIM and confocal microscopy showed a large number of IBA1-expressing TDZD-8 in all parts of the human cochleae (Fig. 1). IBA1, the microglial and macrophage-specific calcium-binding protein, is involved in the membrane ruffli

• To date glycine receptors have been

  2022-07-29

  

  To date, glycine receptors have been found in five distinct transmembrane protein subunits (one β subunit and four α subunit (α1–α4)), combining to form two different types of functional receptors [4], [14], either α homomeric, the immature extrasynaptic glycine receptor subtype, or αβ heteromeric,

• br Introduction Atherothrombosis is associated with the pres

  2022-07-29

  

  Introduction Atherothrombosis is associated with the presence of a low-grade, subclinical smoldering inflammatory response [1]. Several inflammatory markers, among them high-sensitive C-reactive protein (hs-CRP) [2], the erythrocyte sedimentation rate (ESR) [3], fibrinogen concentrations [4], int

• The expression of GLUT receptors

  2022-07-29

  

  The expression of GLUT receptors throughout the body could be considered a potential source for off-target effects even for engineered glucose-conjugated nanomedicines, as there are at least 12 types of GLUT transporters in the body, including GLUT1 in erythrocytes and the blood-brain barrier, as we

• br Experimental br Results br

  2022-07-29

  

  Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,

• Although in in vitro analyses GANT

  2022-07-29

  

  Although in in vitro analyses GANT61 sensitized Daoy glucagon receptor to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-

• Recently multiple receptor agonists have been

  2022-07-29

  

  Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 20

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