• br Acknowledgments This research was

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  Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio

• CHIR-124 br Acknowledgements This work was supported by the

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  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after CHIR-124 formation [1,2]. While the equine morula uses similar amounts of pyruvate and g

• br Conflict of interest br Acknowledgment M

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  Conflict of interest Acknowledgment M.D.P. lab is supported by the EPFL and Swiss National Science Foundation (SNF grant No. 200020_157153). Introduction As amyloid-β peptide (Aβ) accumulation in the 14613 starts in the very early stages of Alzheimer’s disease (AD) pathology (Bateman et a

• Dihydrotestosterone Based on the previous report that

  2022-04-13

  

  Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat

• In a follow up study the same

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  In a follow up study, the same research group further characterized FFA4 involvement in DU145 and PC-3 cancer cell lines by demonstrating that the anti-proliferative and anti-migration activities of FFA4 require the presence of LPA1 receptor (LPA1R), suggesting a mechanism consistent with negative c

• In addition to the four classical FGFRs there is an

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  In addition to the four classical FGFRs there is an additional receptor, FGFR like-1 (FGFRL1, also known as FGFR5) (Ornitz and Itoh, 2015, Trueb et al., 2003). FGFRL1 gene was discovered in a cartilage specific cDNA library in 2000 (Trueb, 2011, Trueb et al., 2003) and thereafter it has been found i

• FDP is considered as key intermediate in the isoprenoid bios

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  FDP is considered as key intermediate in the isoprenoid biosynthetic pathway, since it is the common precursor of polyisoprene units and farnesylated proteins (Cao et al., 2012). In order to understand the role of FDP gene in rubber-producing plants it is of critical importance to mao inhibitors and

• Introduction Human immunodeficiency virus HIV persue to be

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  Introduction Human immunodeficiency pyruvate dehydrogenase kinase inhibitor (HIV) persue to be a major global public health problem (Joint United Nations Programme on HIV/AIDS, 2018). Globally, 36.9 million (range, 31.1 million–43.9 million) people were living with HIV in 2017 (UNAIDS, 2018a). The

• br Introduction Ovarian cancer patients

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  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer NNC 55-0396 with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation in

• br Discussion Our results showed that the histamine

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  Discussion Our results showed that the histamine H1 receptor antagonist/inverse agonists, pyrilamine and cetirizine, attenuated not only NMDAR-mediated synaptic current but also LTP in Shaffer collateral-CA1 pyramidal neuron synapses. The H1 receptor antagonist/inverse agonist-induced attenuation

• br Acknowledgments This research was funded by generous gran

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  Acknowledgments This research was funded by generous grants from the Singapore National Medical Research Council (NMRC CBRG grant NMRC/CBRG12Nov114 (BD)). WJC is supported by NMRC Clinician Scientist Investigator award and partly supported by a Singapore Cancer Syndicate Grant, the National Resea

• br Funding br Conflict of

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  Funding Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Recent papers have shown that Interferon-free hepatitis C virus (HCV) therapies with

• The present results indicate that oxidative damage in CFS mu

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  The present results indicate that oxidative damage in CFS muscles is not due to the decline in the efficiency of antioxidative enzymes. This suggests that there is an increase in the generation of reactive oxygen species consistent with a mitochondrial origin of the damage. Mitochondria represent th

• br Conclusion br Disclosure of interest br Acknowledgement b

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  Conclusion Disclosure of interest Acknowledgement Introduction Vitamin B6 has long been recognized as a cofactor for many enzymes, especially those involved in amino 2 deoxy d glucose australia metabolism. Apart from its role as coenzyme, recent studies are unveiling a new role of vitam

• br Disclosure statement br Introduction Nitro phenylethane

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  Disclosure statement Introduction 1-Nitro-2-phenylethane is the first nitro compound isolated from plants [1]. It is a volatile compound found in the essential oil of various species, and its presence provides a pleasant odor that resembles the cinnamon scent [2]. The biogenesis of 1-nitro-2-p

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