• br Conclusion Membrane transporters remain relatively unders

  2021-09-27

  

  Conclusion Membrane transporters remain relatively understudied in human disease, especially TBI (Cesar-Razquin et al., 2015), and considerably less is known in terms of expression, function and substrates of membrane transporters in pediatric patients. However, their importance in maintaining ba

• br Discussion The Pro Ala variant in PPARG

  2021-09-27

  

  Discussion The Pro12Ala variant in PPARG has been one of the first candidate SNPs for type 2 diabetes [16], [17]. The rare allele of this variant is associated with a 25% reduced risk for the disease [18]. Given the role of PPARG as both a receptor for NEFA and itself a regulator of fat metabolis

• PBI is an agonist of GPR and acts

  2021-09-27

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• In the present study we tested glucosidase and

  2021-09-26

  

  In the present study, we tested α-glucosidase and tyrosinase inhibitory effects of the methanol extract from lower stems and d-cycloserine of Q. coccifera (1) as well as the isolated compounds [lyoniresinol-9-O-β-xylopyranoside (2) and lyoniresinol-9-O-β-glucopyranoside (3), cocciferoside (4), (-)-

• br STAR Methods br Acknowledgments We would like

  2021-09-26

  

  STAR★Methods Acknowledgments We would like to thank Dr. Xiping Cheng for help with the immunohistochemistry staining, Qi Su for help with gene expression analysis, and Dr. Chaoying Liang at the UTSW Genomics Microarray Core facility for assistance on RNA-seq. W.-H.L. was supported by grant awa

• br FXR expression in normal intestine and cancer Of

  2021-09-26

  

  FXR you can find out more in normal intestine and cancer Of note, there are several question marks about FXR post-translational modifications (such as acetylation or SUMOylation) and their involvement in the pathogenesis of metabolic and inflammatory disease (Balasubramaniyan et al., 2013, Kempe

• br Results br Discussion The inflammasome consists

  2021-09-26

  

  Results Discussion The inflammasome consists of the sensor molecule nucleotide oligomerization domain (NOD)-like receptors (NLRs), the adaptor protein ASC, and the myelin basic protein molecule CASP1 (Guo et al., 2015). Among the different types of inflammasome, the NLRP3 inflammasome require

• During the activation of the coagulation cascade factor Xa F

  2021-09-26

  

  During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium PPACK Dihydrochloride mg on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directl

• br Methods br Results We have previously used

  2021-09-26

  

  Methods Results We have previously used ß-hex assays in HeLa Melatonin to study the role of lysosomal exocytosis on transition metal clearance and the effects of transition metals on lysosomal exocytosis [26], [29], [40]. ß-hex is a lysosomal enzyme, the delivery of which to the extracellular

• Cx is a phosphoprotein that is predominantly phosphorylated

  2021-09-26

  

  Cx43 is a phosphoprotein that is predominantly phosphorylated in the control state. Cx43 can be phosphorylated by a number of kinases and dephosphorylated by protein phosphatases such as PP1 and PP2A [6], [10]. Posttranslational phosphorylation of Cx43 is thought to influence intercellular coupling

• Of note the intracellular egg compartment

  2021-09-26

  

  Of note, the intracellular egg compartment exhibiting SA-β-gal activity also exhibits lipofuscin auto-fluorescence (Fig. 6B), and it is co-stained with the lipid-specific dye SBB (Supplemental Fig. 5). On the one hand, these findings reflect the fact that the pool of yolk protein contains lipoprotei

• The galactosidase from Aspergillus oryzae

  2021-09-26

  

  The β-galactosidase from Aspergillus oryzae is a monomeric enzyme of 113 kDa [58] that has been widely used in GOS synthesis [49,53,[59], [60], [61]], exhibiting a high activity of lactose transgalactosylation [62]. Different immobilization methods have been used for the synthesis of lactose-derived

• egfr pathway br FXR expression in normal intestine and cance

  2021-09-26

  

  FXR egfr pathway in normal intestine and cancer Of note, there are several question marks about FXR post-translational modifications (such as acetylation or SUMOylation) and their involvement in the pathogenesis of metabolic and inflammatory disease (Balasubramaniyan et al., 2013, Kemper et al.,

• The even bigger surprise was the second feature

  2021-09-26

  

  The even bigger surprise was the second feature of both structures. Interestingly, binding of the MRG domain hardly altered the conformation of the SET domain compared with its apo state (An et al., 2011). What did change, however, is the conformation of the ASH1L auto-inhibitory loop (Figure 1). De

• In the previous study concerning HO mediated

  2021-09-26

  

  In the previous study concerning HO-1-mediated inhibtion of HCV replication, the mechanism underlying IFN-α/β indcuction by HO-1 involved in HO-1-catalyzed heme metabolic product, biliverdin (Zhu et al., 2010; Lehmann et al., 2010). However, in the present study SnPP, an inhibitor of HO-1 enzymatic

14209 records 547/948 page Previous Next First page 上5页 546547548549550 下5页 Last page