For this reason we hypothesized that

2019-08-28

For this reason we hypothesized that the DHFR gene could be a potential candidate in clefting. Our data, obtained using a family-based association approach, evidenced an association with borderline significance for the SNP rs1677693.

There is a considerable molecular genetic heterogeneity with

2019-08-27

There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions.

The instructive precedent for galectin phosphorylation is hu

2019-08-26

The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1.

Compounds that interact with MDR can do so by different

2019-08-24

Compounds that interact with MDR1 can do so by different mechanisms. Verapamil is known to modulate drug resistance by acting as a competitive MDR1 substrate [36].

The inhibition of CYP activity

2019-08-23

The inhibition of CYP11β activity by NOR was 11- and 2.5-fold higher than those reported for the antifungal agents ketoconazole (IC50: 4.4μM) and clotrimozole (IC50: 1.0μM) (Fernandes and Porte, 2013).

Four m thick sections of formalin fixed

2019-08-22

Four-μm thick sections of formalin-fixed paraffin-embedded tissue samples from uterine cervical cancers were cut with a microtome and dried overnight at 37 °C on a silanized-slide (Dako, Carpentaria, CA, USA).

br Discussion The regulation of intracellular cholesterol le

2019-08-21

Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control.

PPACKII Another well established visceral action of CRF and

2019-08-20

Another well-established visceral action of CRF and urocortin administered peripherally is the long-lasting lowering of blood pressure observed in various species ranging from rodents to humans [22].

br Results br Discussion Unraveling

2019-08-19

Discussion Unraveling the molecular details of nucleoporin-karyopherin interactions, which have to be strong enough to promote transport but sufficiently weak to avoid stalling of transport complexes within the pore, is key to our understanding of the mechanisms of nucleocytoplasmic transport.

br Materials and methods br Results

2019-08-17

Discussion To date, several reports have suggested an involvement of DGK in bipolar disorder. A splice variant at the COOH-terminus of DGKβ has been related to bipolar disorder [15] and DGKβ KO mice showed hyperactive behavior [17].

If the unwanted objects detected by OpenComet are manually d

2019-08-16

If the unwanted objects detected by OpenComet are manually deleted, and then the DNA (%) in tail is computed, the performance of the present method can be compared more effectively.

Ubiquitination can occur on a single monoubiquitination or s

2019-08-15

Ubiquitination can occur on a single (monoubiquitination) or several (multiubiquitination) lysine residues, or the same lysine residue can be subjected to several rounds of Ub conjugation (polyubiquitination).

Extracellular uridine can be transported across the cell mem

2019-08-14

Extracellular uridine can be transported across the cell membrane to enter the nucleotide salvage pathway.

The Inhibitor of APoptosis IAP

2019-08-13

The Inhibitor of APoptosis (IAP) proteins were first identified as gene products of baculovirus that inhibited apoptosis of infected insect Dextran (Clem et al., 1991, Crook et al., 1993).

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2018-07-29